Although the hazards of the doses of lipid given in this therapy are not known, for a patient in the desperate circumstance of local anesthetic toxicity and failing or failed resuscitation, lipid emulsion therapy seems to be a worthy and effective consideration. It would be naive to substitute this treatment for standard CPR, but it is not premature to apply it once it is clear that the likely explanation for a patient’s cardiovascular collapse is local anesthetic toxicity and when conventional resuscitation efforts are not generating success. This conclusion is not based on a flash-in-a-pan experiment but rather, on a methodical, scientific evolution of a concept tested in more than one animal model, and now showing dramatic results in a few humans.